University of Rostock
Department of Anatomy
Neuroscience Group
Publications
1995-2011
Wree A, Mix E, Hawlitschka A, Antipova V, Witt M, Schmitt O, Benecke R (2011) Intrastriatal botulinum toxin improves motor function in the 6-OHDA rat model of Parkinson's disease. Neurobiol Dis 41:291-298.
Röwer C, Ziems B, Radtke A, Schmitt O, Reimer T, Koy C, Thiesen H-J, Gerber B, Glocker MO (2011) Toponostics of Invasive Ductal Breast Carcinoma: Combination of Spatial Protein Expression Imaging and Quantitative Proteome Signature Analysis. Int J Clin Exp Path, in press.
Lange C, Mix E, Frahm J, Glass Ä, Mueller J, Schmitt O, Schmöle A-C, Klemm K, Ortinau S, Hübner R, Frech M, Wree A, Rolfs A (2011) Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells. Neurosci Lett 488: 36-40.
Schmitt O, Birkholz H (2011) . Improvement in cytoarchitectonic mapping by combining electrodynamic modeling with local orientation in high-resolution images of the cerebral cortex. Micros Res Techn 74: 225-243.
Schmitt O, Lessner G, Haas SJ-P, Mikkat S, Kreutzer M, Wree A, Glocker MO (2010) The differential proteome of the striatum from hemiparkinsonian rats displays vivid structural remodeling processes. J Prot Res 9: 4671-4687. - Supplemental Material.
Hildebrandt S, Schmidt A, Stoll A, Schmitt O, Köhling R, Wree A, Haas SJ-P, Pützer BM (2010) Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors. Brain, Struct Funct 215:105-113.
Usunoff KG, Lazarov NE, Itzev DE, Schmitt O, Rolfs A, Wree A (2010) Projections from the central amygdaloid nucleus to the mesencephalic trigeminal nucleus in the rat. Acta morph anthrop, 15: 11-15.
Claassen H, Schmitt O, Wree A (2010) Superficial arm arteries revisited: Brother and sister with absent radialis pulse. Ann Anat 192: 151-155.
Hovakimyana M, Spasova M, Wree A, Schmitt O (2010) In vitro differentiation of the mmortalized mesencephalic progenitor cell line CSM14.1 occurs independently from haematopoietic cytokines. Cell Molec Biol, 56: 1252-1260.
Schmitt O, Birkholz H (2010) A hybrid approach to quantify lamination of the cerebral cortex. Int J Nonlin Sci Sim 10: 1655-1661.
Lazarov NE, Usunoff KG, Schmitt O, Itzev DE, Rolfs A, Wree A (2010) Amygdalotrigeminal projection in the rat: An anterograde tracing study. Ann Anat 193:118-126.
Usunoff K, Schmitt O, Dimitar I,Haas S-JP, Lazarov N, Rolfs A, Wree A (2009) Efferent projections of the posterodorsal part of the medial nucleus of the amygdala in the mouse. Cells, Tissues & Organs, 190: 256-285.
Schmitt O, Reetz S (2009) On the decomposition of cell clusters. J Math Img Vis, 33: 85-103.
Schmitt O, Hasse M (2009) Morphological multiscale decomposition of connected regions with emphasis on cell clusters. Comp Vis Image Under 113: 188-201.
Schmitt O, Bethke S, Sobe P, Prehn S, Maehle E (2008) Parallelized segmentation of a serially sectioned whole human brain. Img Vis Comp 26: 289-301.
Schmitt O, Hasse M (2008) Radial symmetries based decomposition of cell clusters in binary and gray level images. Pat Rec 41: 1905-1923.
Usunoff KG, Schmitt O, Lazarov NE, Itzev DE, Rolfs A, Wree A (2008) Efferent projections of the claustrum to the dorsal and ventral striatum, substantia nigra, ventral tegmental area and parabrachial nuclei. Retrograde tracing study in the rat. Comptes Rendus de l'Academie Bulgare des Sciences, 61: 817-825.
Usunoff KG, Schmitt O, Lazarov NE, Itzev DE, Rolfs A, Wree A (2008) Differential projections to the dorsal and ventral striatum from the dopaminergic, noradrenergic, serotonergic and cholinergic neuronal groups of the brain stem. A retrograde tracing study in the rat. Comptes Rendus de l'Academie Bulgare des Sciences, 61: 945-954.
Usunoff KG, Schmitt O, Lazarov NE, Itzev DE, Rolfs A, Wree A (2008) Nitric oxide-producing neurons in the amygdaloid nuclear complex of the rat. Comptes Rendus de l'Academie Bulgare des Sciences, 61: 1357-1366.
Usunoff KG, Schmitt O, Lazarov NE, Itzev DE, Rolfs A, Wree A (2008) Amygdala and subcortical vision: Recognition of threat and fear. Biomed Rev 19: 1-16.
Haas SJ-P, Petrov S, Kronenberg G, Schmitt O, Wree A (2008) Orthotopic transplantation of immortalized mesencephalic progenitors (CSM14.1-cells) into the substantia nigra of Hemiparkinsonian rats induces neuronal differentiation and motoric improvement. J Anat 212: 19-30.
Hovakimyan M, Haas SJ-P, Schmitt O, Gerber B, Wree A, Andressen C (2008) Mesencephalic human neural progenitor cells transplanted into the adult hemiparkinsonian rat striatum improve motor behavior. Cells Tissues Organs 188: 373-383.
Usunofff KG, Schmitt O, Itzev DE, Rolfs A, Wree A (2007) Efferent connections of the parabigeminal nucleus to the amygdala and the superior colliculus in the rat. A double labeling fluorescent retrograde tracing study. Brain Res 1133: 87-91.
Schmitt O, Modersitzki J, Heldmann S, Wirtz S, Fischer B (2007) Image registration of sectioned brains. Int J Comp Vis 73: 5-39.
Haas SJ-P, Beckmann S, Petrov S, Andressen C, Wree A, Schmitt O (2007). Transplantation of immortalized mesencephalic progenitors (CSM14.1-cells) into the neonatal Parkinsonian rat caudate putamen. J Neurosci Res 85: 778-786.
Claassen H, Schmitt O, Wree A (2007) Large patent median arteries and their relation to the superficial palmar arch by means of history, size consideration and clinic consequences. Surg Rad Anat 30: 57-63.
Hawlitschka A, Haas S, Schmitt O, Wree A (2007) Effects of proteasome inhibition on catecholaminegergic cells in brain, adrenal medulla and carotid body in Wistar rats. Brain Res 1173: 137-144.
Usunoff KG, Itzev DE, Lazarov NE, Schmitt O, Rolfs A, Wree A (2007) Interconnection between the central amygdaloid nucleus and the bed nucleus of stria terminalis in the rat. An anterograde and retrograde tracing study. Compt Rend Acad Bulg Sci 60: 1127-1132.
Usunoff KG, Lazarov NE, Itzev DE, Schmitt O, Rolfs A, Wree A (2007) Cholinergic neuronal systems of the amygdala in the rat. An immuncytochemical study. Compt Rend Acad Bulg Sci 60: 1215-1220.
Nishino T, Wedel T, Schmitt O, Schönfelder M, Hirtreiter C, Schulz T, Kühnel W, Michna H (2006) The xenoestrogen Bisphenol A in the hershberger assay: androgen receptor regulation and morphometrical reactions indicate no major effects. J Steroid Biochem 98: 155-163.
Claassen H, Schmitt O, Wree A (2006) Variations of the A. axillaris and the crural arteries in the same human indicidual - multiple repetions of the mammalian plesiomorphic condition of arteries. Ann Anat 188: 39-48.
Hovakimyan M, Haas SJ-P, Schmitt O, Gerber B, Wree A, Andressen C (2006) Mesencephalic human neural progenitor cells transplanted into the neonatal hemiparkinsonian rat striatum differentiate into neurons and improve motor behavior. J Anat 209: 721-732.
Usunofff KG, Itzev DE, Rolfs A, Schmitt O, Wree A (2006) Nitric oxide synthase-containing neurons in the amygdaloid nuclear complex of the rat. Anat Embryol 211: 721-737.
Riehemann K, Schmitt O, Ehlers E (2005) The effects of a combined thermochemotherapy using cyclophosphamide plus hyperthermia on the malignant pleural mesothelioma in vivo. Ann Anat 187: 215-223.
Schmitt O, Eggers R, Modersitzki J (2005) Videomicroscopy, image processing, and analysis of whole histologic sections of the human brain. Micros Tech Res 66: 203-218.
Wree A, Itzev DE, Schmitt O, Usunoff KG (2005) Neurons in the dorsal column nuclei of the rat emit a moderate projection to the ipsilateral ventrobasal thalmus. Anat Embryol 210: 155-162
Wirtz S, Papenberg N, Fischer B, Schmitt O (2005) Robust and staining-invariant elastic registration of a series of images from histologic slices. SPIE 5747: 1256-1262.
Schmitt O, Modersitzki J, Heldmann S, Wirtz S, Hömke L, Heide W, Kömpf D, Wree A (2005) Three-dimensional cytoarchitectonic analysis of the posterior bank of the human precentral sulcus. Anat Embryol 210: 387-400
Usunoff KG, Popratiloff A, Schmitt O, Wree A (2005) Functional neuroanatomy of pain. Advances in Anatomy 184.
Nishino T, Wedel T, Schmitt O, Bühlmeyer K, Schönfelder M, Hirtreiter C, Schulz T, Kühnel W, Michna H (2004) Androgen-dpendent morphology of prostates and seminal vesicles in the Hershberger assay: Evaluation of immunohistochemical and morphometric parameters. Ann Anat 186: 247-253
Schmitt O, Preuße S, Haas SJP (2004) Comparison of contrast, sensitivity and efficiency of signal amplified and nonamplified immunohistochemical reactions suitable for videomicroscopy based quantification and neuroimaging. Brain Res Meth 12: 157-171
Schmitt O, Pakura M, Aach T, Hömke, L, Böhme M, Bock S (2004) Analysis of nerve fibres and their distribution in histologic sections of the human brain. Micr Res Tech 63: 220-243
Haas SJ-P, Ahrens A, Petrov S, Schmitt O, Wree A (2004) Quinolinic acid lesions of the caudate putamen in the rat lead to an increase of CTNF. J Anat 204: 271-281.
Wirtz S, Fischer B, Modersitzki J, Schmitt O (2004) Super-fast elastic registration histologic images of a whole rat brain for three-dimensional reconstruction. SPIE, 5370: 1-7.
Schmitt O, Hömke L, Dümbgen L (2003) Detection of cortical transition regions utilizing statistical analyses of excess masses. NeuroImage 19: 42-63
Schmitt O, Mecke E, Lau P, Almert U, Bock S, Böhme M, Pakura M, Aach T, Hömke L, Reusche E, Heide W, Kömpf D, Dümbgen L (2002) Parameterkarten neuronaler Faserprozesse im menschlichen Cortex cerebri. Focus MUL 19: 74-81
Schmitt O, Schubert C, Feyerabend T, Hellwig-Bürgel T, Weiss C, Kühnel W (2002) Preferential topography of proteins regulating vascularization and apoptosis in MX1 xenotransplant after treatment with hypoxia, hyperthermia, ifosfamide, and irradiation. Am J Clin Oncol 25: 325-336
Schmitt O, Böhme M (2002) A robust transcortical profile scanner for generating 2D-traverses in histological sections of rich curved cortical courses. NeuroImage 16: 1103-1119
Pakura M, Schmitt O, Aach T (2002) Segmentation and analysis of nerve fibers in histologic section of the human cerebral cortex. IEEE Southwest Symposium on Image Analysis and Interpretation, April 7 9, 2002, Santa Fe, New Mexico, SSIAI 2002: 62 66
Ressel A, Schmitt O, Weiss C, Feyerabend T (2002) Therapeutic outcome and side-effects after radiotherapy, chemotherapy and/or hyperthermia treatment of head and neck tumour xenografts. Europ J Canc 38: 594-601
Gruber H, Brenner E, Schmitt O, Fritsch H (2001) The different growth zones of the fetal foot. Ann Anat 183: 267-273
Schmitt O, Modersitzki J (2001) Registrierung einer hochaufgelösten histologischen Schnittserie eines Rattenhirns. Workshop Bildverarbeitung in der Medizin (BVM 2001), Informatik aktuell: 174-178
Modersitzki J, Schmitt O (2001) Effiziente, nicht lineare Registrierung eines histologischen Serienschnittes durch das menschliche Gehirn. Workshop Bildverarbeitung in der Medizin (BVM 2001), Informatik aktuell: 179-183
Marxen J, Schmitt O, Metzen E, Jelkmann W, Hellwig-Bürgel T (2001) Vascular endothelial growth factor gene expression in the human breast cancer cell line MX-1 is controlled by O2 availability in vitro and in vivo. Ann Anat 183: 243-249
Modersitzki J, Lustig G, Schmitt O, Obelöer W (2001) Elastic registration of brain images on large PC-Clusters. Future Generation Computer Systems 18: 115-125
Roudenok V, Schmitt O (2000) Upregulation of vasoactive intestinal polypeptide (VIP) and calcitonin gene related peptide (CGRP) expression in stellate ganglia of children with congenital cardiovascular lesions. Ann Anat 183: 209-212
Schmitt O, Eggers R, Haug H (2000) Topological distribution of different types of neurons in the human putamen. Anal Quant Cytol 22: 155-167
Schmitt O, Eggers R (1999) Flat-bed scanning as a tool for quantitative neuroimaging. J Microsc 196: 337-346
Leffler A, Ludwig M, Schmitt O, Busch LC (1999) Germ cell migration and early development of the gonads in the trisomy 16 mouse—an animal model for Downs syndrome. Ann Anat 181: 1-6
Preuße S, Schmitt O (1999) Quantification and comparison of signal amplification and non-amplificated immunohistochemical reactions of the rat brain by means of image analysis. Elect J Path Hist 5.3, Artikelnr.: 993-03
Schmitt O, Eggers R, Mendoza A, Szabo K, Feyerabend T, Weiss C, Kühnel W (1999) Stereologic evaluation of the vasculature in a MX1 xenotransplanted tumour model after combinations of treatment with ifosfamide, hyperthermia and irradiation. In J Hyperthermia 15: 237-250
Modersitzki J, Obelöer W, Schmitt O, Lustig G (1999) Elastic matching of very large scale digital images on high performance clusters. Proc. 7th International Conference on High Performance Computing and Networking, Amsterdam, 12.-14.4., Lecture Notes of Computer Science 1593: 141-149
Schmitt O, Almert U, Mecke E, Eggers R (1998) Die quantitative Zytoarchitektonik der Areale nach Brodmann des menschlichen Cortex cerebri. Focus MUL 15: 144-155
Schmitt O, Eggers R (1997) A high contrast and homogeneous staining of paraffin sections of whole human brains for 3D ultrahigh resolution image analysis. Biotech Histochem 73: 44-51
Schmitt O, Eggers R (1997) Systematic investigations of the contrast results of histochemical stainings of neurons and glial cells in the human brain by means of image analysis. Micron 28: 197-215
Schmitt O, Eggers R, Haug H (1995) Quantitative investigations into the histostructural nature of the human putamen. I. Staining, cell classification and morphometry. Ann Anat 177: 243-250
Schmitt O, Eggers R, Haug H (1995) Quantitative investigations into the histostructural nature of the human putamen. II. The differentiated topological distribution of certain neuron type arrangements. Ann Anat 177: 455-465
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